AB034. Application of Y chromosome microdeletions analysis in reproductive dysfunction
نویسنده
چکیده
Male factor infertility often happened in patients with varicocele and genetic disorder. Microsurgical varicocele is the most effective and safe treatment option for male infertility in patients with varicocele. Y chromosome microdeletions and chromosomal abnormalities are the two types of genetic disorder. Now we could use commercial detection kits through PCR amplification of selected regions of the Y chromosome. In this report, I will introduce the application of Y chromosome microdeletions analysis in clinical reproductive dysfunction.
منابع مشابه
Frequency of Y Chromosome Microdeletions in Azoospermic and Oligospermic Iranian Infertile Men
Background and Aims: Azoospermia factor (AZF) region of the Y-chromosome has several genes which are responsible for normal spermatogenesis. Microdeletions of these genes are associated with azoospermia and oligospermia. These microdeletions are too small to be detected by karyotyping. They can be easily identified using polymerase chain reaction. The aim of this study is to determine the frequ...
متن کاملO-7: Y Chromosome Microdeletions Are Not Associated with Spontaneous Recurrent Pregnancy Loss in A Sinhalese Population in Sri Lanka
Background: Many advances have been made in reproductive medicine yet the spontaneous loss of a pregnancy remains the most common complication of pregnancy. The aetiology of spontaneous recurrent pregnancy loss (RPL) is multifactorial. Y chromosome microdeletions are found in approximately 7% of men with low sperm counts and, compared to the general population, a higher frequency of spontaneous...
متن کاملPartial and complete microdeletions of Y chromosome in infertile males from South of Iran
Y chromosome microdeletions are the second genetic cause of male infertility. The incidence of Y chromosome microdeletions can vary considerably depending on several factors, including patient selection criteria, population composition, and diagnostic protocols. They are associated with spermatogenic failure and lead to azoospermia or oligozoospermia. The advance in assisted reproductive techno...
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Male factor infertility often happened in patients with varicocele and genetic disorder. Microsurgical varicocele is the most effective and safe treatment option for male infertility in patients with varicocele. Y chromosome microdeletions and chromosomal abnormalities are the two types of genetic disorder. Now we could use commercial detection kits through PCR amplification of selected regions...
متن کاملO-1: Evaluation of Ethnic Patterns of Y Chromosome Microdeletions in Iranian Infertile Men with Azoospermia/Severe Oligospermia Referred to Royan Institute
Background: Microdeletions of the long arm of the chromosome Y are the most common molecular genetic cause of severe infertility in men which affect three regions of AZFa, AZFb and AZFc (Azoospermia factor). These regions contain various genes involved in spermatogenesis. The effect of ethnicity on the patterns of Y chromosome microdeletions has not been extensively studied, particulary in Iran...
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